User blog comment:AikawaAyumu/After GREMLIN storyline is over.../@comment-11612775-20130904165720

Well, currently, Kihara Yuitsu (and Noukan to an extent) seems the closest we have to an upcoming next main antagonist (at least from the Science Side).

If Number Six were to step out of the shadows and become the next storyline antagonist, it would be rather refreshing, instead of how the other Level 5 Espers who were either manipulated(Accelerator and Kakine) or hadn't any particularly large agenda(s), like Mugino.

Especially if he/she menages to remain a legitimate threat to Touma and co, as well as to Aleister's plan(s) and also have a proper tragic or justification. Given the existence of the FIVE_OVER series of weapons and cyborgs like Rensa (limited due to great expenses, however) and Capacity Down, it would be really cool if #6 could somehow outmaneuver all of it, thus being something like a self-destruct button in Aleister's plan(s). Or perhaps even try to hijack it somehow...